Cover Feature: Molecular Structure of Binary Chromium(III)–DNA Adducts (ChemBioChem 5/2020)

Chromate compounds are carcinogenic when inhaled, but the mechanism of tumorigenesis is unknown. One hypothesis involves transport of chromium into cells where reduction to chromium(III) and binding of the chromium(III) to DNA occurs. The elucidation of the molecular‐level structures of the resultin...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2020-03, Vol.21 (5), p.575-575
Main Authors: Brown, Silas, Lockart, Molly M., Thomas, C. Sumner, Bowman, Michael K., Woski, Stephen A., Vincent, John B.
Format: Article
Language:English
Subjects:
chromium
DNA
ESEEM
oligonucleotides
paramagnetic NMR spectroscopy
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Summary:Chromate compounds are carcinogenic when inhaled, but the mechanism of tumorigenesis is unknown. One hypothesis involves transport of chromium into cells where reduction to chromium(III) and binding of the chromium(III) to DNA occurs. The elucidation of the molecular‐level structures of the resulting metal–DNA adducts forms a crucial bridge between exposure to the carcinogen and the development of mutations and cancer in humans. More information can be found in the communication by J. B. Vincent et al. on page 628 in Issue 5, 2020 (DOI: 10.1002/cbic.201900436).
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202000078