Front Cover: Constraining and Modifying Peptides Using Pd‐Mediated Cysteine Allylation (ChemBioChem 13/2023)

Pd‐mediated cysteine allylation allows to constrain and rigidify peptides by linking two cysteine side chains with a large set of easily available stapling reagents. The staple itself can be further functionalized based on its inherent reactivity thereby allowing construction of a large variety of s...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2023-07, Vol.24 (13), p.n/a
Main Authors: Kriegesmann, Julia, Schlatzer, Thomas, Che, Kateryna, Altdorf, Claudia, Huhmann, Susanne, Kählig, Hanspeter, Kurzbach, Dennis, Breinbauer, Rolf, Becker, Christian F. W.
Format: Article
Language:English
Subjects:
allylation reaction
Diels-Alder reaction
peptide stapling
secondary peptide modification
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Summary:Pd‐mediated cysteine allylation allows to constrain and rigidify peptides by linking two cysteine side chains with a large set of easily available stapling reagents. The staple itself can be further functionalized based on its inherent reactivity thereby allowing construction of a large variety of solid peptides. More information can be found in the Research Article by C. F. W. Becker et al.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202300340