Methylaluminoxane as an Alternative for BArF in the Iridium-Catalyzed Asymmetric Hydrogenation of Imines

An ionic revolution? BArF has been the anion of choice for iridium‐catalyzed imine hydrogenation; however, for large‐scale production its use may be too costly. Methylaluminoxane (MAO) can be used instead in conjunction with [{Ir(COD)Cl}2], although enantioselectivities are somewhat lower than with...

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Bibliographic Details
Published in:ChemCatChem 2011-07, Vol.3 (7), p.1139-1142
Main Authors: Mršić, Nataša, Panella, Lavinia, IJpeij, Edwin G., Minnaard, Adriaan J., Feringa, Ben L., de Vries, Johannes G.
Format: Article
Language:English
Subjects:
asymmetric catalysis
hydrogenation
imines
iridium
methylaluminoxane
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Summary:An ionic revolution? BArF has been the anion of choice for iridium‐catalyzed imine hydrogenation; however, for large‐scale production its use may be too costly. Methylaluminoxane (MAO) can be used instead in conjunction with [{Ir(COD)Cl}2], although enantioselectivities are somewhat lower than with BArF if 50–500 eq. of MAO are used.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201100008