Integration of Reverse-Osmosis Unit Operations in Biotechnology Process Design

The stepwise process design approach, proposed in a previous study, to generally model membrane unit operations in combination with experimental model parameter determination is transferred to a reverse‐osmosis unit. In order to predict the purification a priori by simulations, the changes of the ri...

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Bibliographic Details
Published in:Chemical engineering & technology 2012-01, Vol.35 (1), p.191-197
Main Authors: Grote, F., Fröhlich, H., Strube, J.
Format: Article
Language:English
Subjects:
Biotechnology
Membrane unit
Modeling
Reverse osmosis
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Summary:The stepwise process design approach, proposed in a previous study, to generally model membrane unit operations in combination with experimental model parameter determination is transferred to a reverse‐osmosis unit. In order to predict the purification a priori by simulations, the changes of the rigorous ultrafiltration model to gain a rigorous reverse‐osmosis model are described. The modular process model, combining the most limiting factors within one mathematical model, is transmitted to reverse osmosis and various filtrations are carried out. Together with the new standard laboratory equipment, practicability of the proposed buildup is proven in order to design and integrate reverse‐osmosis membranes into biotechnology processes. The previously proposed new stepwise approach to model membrane unit operations generally in combination with experimental model parameter determination was successfully transferred to a reverse‐osmosis unit. Together with lab‐scale experiments it was demonstrated that prediction of the purification performance a priori by simulations for unknown multicomponent salt mixtures is possible.
ISSN:0930-7516
1521-4125
DOI:10.1002/ceat.201100182