Fast and Efficient 18 F‐Labeling by [ 18 F]Fluorophenylazocarboxylic Esters

Introduction of [ 18 F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30 seconds, with radiochemical yields of up to 95 % (85(±10) %). For labeling purposes, the resulting 18 F‐substituted azoester can be further converted in radical‐arylation reactions to giv...

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Bibliographic Details
Published in:Chemistry : a European journal 2014-01, Vol.20 (2), p.370-375
Main Authors: Fehler, Stefanie K., Maschauer, Simone, Höfling, Sarah B., Bartuschat, Amelie L., Tschammer, Nuska, Hübner, Harald, Gmeiner, Peter, Prante, Olaf, Heinrich, Markus R.
Format: Article
Language:English
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Summary:Introduction of [ 18 F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30 seconds, with radiochemical yields of up to 95 % (85(±10) %). For labeling purposes, the resulting 18 F‐substituted azoester can be further converted in radical‐arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201303409