Cover Feature: A Hexavalent Basket for Bottom‐Up Construction of Functional Soft Materials and Polyvalent Drugs through a “Click” Reaction (Chem. Eur. J. 5/2019)

A dual‐cavity host, with six terminal alkynes at the periphery of its two fused cavitands, is obtained at the gram scale by following straightforward synthetic protocols. This structurally unique and multivalent cavitand can be efficiently clicked to carbohydrates, polymers, or small functional mole...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2019-01, Vol.25 (5), p.1115-1115
Main Authors: Neal, Taylor A., Wang, Weikun, Zhiquan, Lei, Peng, Ruojing, Soni, Priti, Xie, Han, Badjić, Jovica D.
Format: Article
Language:English
Subjects:
click reaction
drug design
molecular recognition
multivalency
supramolecular chemistry
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A dual‐cavity host, with six terminal alkynes at the periphery of its two fused cavitands, is obtained at the gram scale by following straightforward synthetic protocols. This structurally unique and multivalent cavitand can be efficiently clicked to carbohydrates, polymers, or small functional molecules. The stage is thus set for exploring the preparation of novel multivalent drugs and nanostructured soft materials. More information can be found in the Full Paper by J. D. Badjić et al. on page 1242.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201806120