Cover Feature: Absolute Configuration Assignment from Optical Rotation Data by Means of Biphenyl Chiroptical Probes (Chem. Eur. J. 22/2019)

A central‐to‐axial chirality transfer occurring when chiral molecules are linked to flexible biphenyl probes makes it possible to assign their absolute configuration from the biphenyl twist. By employing 4,4’‐disubstituted biphenyls, the twist sign, and then the absolute configuration, can be reveal...

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Bibliographic Details
Published in:Chemistry : a European journal 2019-04, Vol.25 (22), p.5597-5597
Main Authors: Vergura, Stefania, Scafato, Patrizia, Belviso, Sandra, Superchi, Stefano
Format: Article
Language:English
Subjects:
absolute configuration
biphenyls
chiroptical probes
circular dichroism
optical rotation
Online Access:Get full text
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Summary:A central‐to‐axial chirality transfer occurring when chiral molecules are linked to flexible biphenyl probes makes it possible to assign their absolute configuration from the biphenyl twist. By employing 4,4’‐disubstituted biphenyls, the twist sign, and then the absolute configuration, can be revealed by the sign of optical rotation. This allows for assignment of the absolute configuration of chiral α‐substituted carboxylic acids and primary amines in a non‐empirical and straightforward way by simple [α]D measurements. More information can be found in the Full Paper by S. Superchi et al. on page 5682.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201901165