Front Cover: Engineering of Laccase CueO for Improved Electron Transfer in Bioelectrocatalysis by Semi‐Rational Design (Chem. Eur. J. 22/2020)

Copper efflux oxidase (CueO) from Escherichia coli is a special bacterial laccase due to its fifth copper binding site. In contrast with previous reports, this work illustrates the relationship between the fifth copper region and electrocatalytic properties. Through a semi‐rational design, an increa...

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Bibliographic Details
Published in:Chemistry : a European journal 2020-04, Vol.26 (22), p.4880-4880
Main Authors: Zhang, Lingling, Cui, Haiyang, Dhoke, Gaurao V., Zou, Zhi, Sauer, Daniel F., Davari, Mehdi D., Schwaneberg, Ulrich
Format: Article
Language:English
Subjects:
bioelectrocatalysis
copper efflux oxidase
electron transfer
oxygen reduction reaction
site-saturation mutagenesis
Online Access:Get full text
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Summary:Copper efflux oxidase (CueO) from Escherichia coli is a special bacterial laccase due to its fifth copper binding site. In contrast with previous reports, this work illustrates the relationship between the fifth copper region and electrocatalytic properties. Through a semi‐rational design, an increase in localized structural stability and a decrease of electron transfer pathway are found to contribute to beneficial CueO variants. It may give clues on how to tailor laccases or other oxidoreductases for bioelectrocatalytic applications. More information can be found in the Full Paper by L. Zhang, U. Schwaneberg, et al. on page 4974.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202001026