Cover Feature: A Cytotoxic Bis(1,2,3‐triazol‐5‐ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation (Chem. Eur. J. 32/2021)

A challenging synthesis yields a bis(carbene) AuI‐CNC pincer precursor complex that may be oxidized to a remarkably redox‐stable [AuIII(CNC)Cl]+ cation which shows significant cytotoxicity towards a breast cancer cell line. Electrophoresis, viscometry, and spectroscopic data suggest the likely mode...

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Bibliographic Details
Published in:Chemistry : a European journal 2021-06, Vol.27 (32), p.8229-8229
Main Authors: Westhuizen, Danielle, Slabber, Cathryn A., Fernandes, Manuel A., Joubert, Daniël F., Kleinhans, George, Westhuizen, C. Johan, Stander, André, Munro, Orde Q., Bezuidenhout, Daniela I.
Format: Article
Language:English
Subjects:
anticancer
cytotoxicity
gold complexes
mesoionic carbenes
metallodrugs
Online Access:Get full text
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Summary:A challenging synthesis yields a bis(carbene) AuI‐CNC pincer precursor complex that may be oxidized to a remarkably redox‐stable [AuIII(CNC)Cl]+ cation which shows significant cytotoxicity towards a breast cancer cell line. Electrophoresis, viscometry, and spectroscopic data suggest the likely mode of interaction of the compound with DNA involves partial intercalation, enabling it to potentially target both conventional and unconventional DNA species such as three‐way junctions (in silico data). More information can be found in the Full Paper by O. Q. Munro, D. I. Bezuidenhout, et al. (DOI: 10.1002/chem.202100598).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202101553