Synthesis of (-)-Cannabidiol (CBD), (-)-Δ 9 - and (-)-Δ 8 -Tetrahydrocannabinols, Encapsulation of CBD with Nanoparticles for Controlled Delivery and Biological Evaluation

Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD in solid and hollow pH-sensitive poly(4-vinylpyridine) (solid@p4VP and hollow...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2024-12, Vol.30 (70), p.e202402496
Main Authors: Moya-Utrera, Federico, Fuentes-Ríos, David, Romero-Carrasco, Antonio, Doña-Flores, Manuel, Cheng-Sánchez, Iván, Díaz-Morilla, Amelia, Soledad Pino-González, María, Martínez-Ferez, Antonio, Moreno, Javier, Mesas, Cristina, Melguizo, Consolación, Prados, José, Sarabia, Francisco, López-Romero, J Manuel
Format: Article
Language:English
Subjects:
A549 Cells
Acrylic Resins - chemistry
Cannabidiol - chemistry
Cannabidiol - pharmacology
Cannabis - chemistry
Dronabinol - chemistry
Dronabinol - pharmacology
Drug Carriers - chemistry
Drug Liberation
Humans
Hydrogen-Ion Concentration
Nanoparticles - chemistry
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD in solid and hollow pH-sensitive poly(4-vinylpyridine) (solid@p4VP and hollow@p4VP) nanoparticles, and temperature-sensitive poly(N-isopropylacrylamide) (solid@pNIPAM and hollow@pNIPAM) nanoparticles for transport and release CBD in a controlled manner. The CBD loading into these smart polymeric systems was effective and their release profiles, solubility and resistance to stomach and intestinal conditions were evaluated, showing satisfactory properties and improved bioavailability with respect to free CBD. Finally, the A549 human lung cancer cell line was used as lung adenocarcinoma epithelial cellular model to carry out preliminary assays of the in vitro activity of the vehiculized CBD. For all these studies, synthetic CBD was employed, for which a new efficient and scalable synthesis of cannabinoids has been developed.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202402496