Front Cover: Solvent‐Free Mechanosynthesis of Oligopeptides by Coupling Peptide Segments of Different Lengths – Elucidating the Role of Cesium Carbonate in Ball Mill Processes (Chem. Eur. J. 44/2024)

The idea of synthesizing oligopeptides by using solvent‐free ball milling is based on the assumption that it is possible to construct different objects using segments (blocks) of different sizes and lengths. It has been shown that by having a “library” of short peptides and using the ball mill mecha...

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Published in:Chemistry : a European journal 2024-08, Vol.30 (44), p.n/a
Main Authors: Wróblewska, Aneta, Bak‐Sypien, Irena I., Paluch, Piotr, Wielgus, Ewelina, Zając, Justyna, Jeziorna, Agata, Kaźmierski, Sławomir, Potrzebowski, Marek J.
Format: Article
Language:English
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Summary:The idea of synthesizing oligopeptides by using solvent‐free ball milling is based on the assumption that it is possible to construct different objects using segments (blocks) of different sizes and lengths. It has been shown that by having a “library” of short peptides and using the ball mill mechanosynthesis (BMMS) method, peptides can be easily combined to form different products with the desired functional and biological properties. The role of Cs2CO3 in the coupling mechanism was followed at each stage of synthesis using magic angle spinning (MAS) NMR techniques. More information can be found in the Research Article by M. J. Potrzebowski and co‐workers (DOI: 10.1002/chem.202400177).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202484401