Physicochemical Characterization of Veronicafolin-β-cyclodextrin and Solubility Enhancement of Veronicafolin-HP-β-cyclodextrin Inclusion Compound

Inclusion complexation between veronicafolin, 3,5,4′‐trihydroxy‐6,7,3′‐trimethoxyflavone, and β‐cyclodextrin (β‐CD) was investigated by using 1H NMR, IR, X‐ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid state. The elemental analysis showed that the complex (1...

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Bibliographic Details
Published in:Chinese journal of chemistry 2005-06, Vol.23 (6), p.775-780
Main Authors: Yun-Shang, Yang, Ying-Peng, Zhang, Ai-Mei, Yang, Run-Hua, Lu, Yan-Ping, Shi, Gao-Feng, Shi
Format: Article
Language:English
Subjects:
hydroxypropyl-β-cyclodextrin
improvement of solubility
inclusion complex
veronicafolin
β-cyclodextrin
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Summary:Inclusion complexation between veronicafolin, 3,5,4′‐trihydroxy‐6,7,3′‐trimethoxyflavone, and β‐cyclodextrin (β‐CD) was investigated by using 1H NMR, IR, X‐ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid state. The elemental analysis showed that the complex (1:1) of flavonol‐β‐CD·20H2O with C 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV‐Vis in solution in the presence of hydroxypfropyl‐β‐cyclodextrin (HP‐β‐CD) was classified as AL‐type, indicating the formation of 1:1 inclusion complex. And the calibration equation y=24148x+0.0075 (r=0.9999) and phase‐solubility diagram y=0.4738x‐2.0×10‐7 (r=0.9490) were obtained. Stability constant Ks was calculated from the phase solubility diagram (Ks=4.5×106). Solubility of the veronicafolin was enhanced in the presence of HP‐β‐CD.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.200590775