Influence of Emulsifiers on the Synthesis of Insulin-loaded Nanocapsules in Double Emulsion

Insulin entrapped nanocapsules to use polylactide (PLA) as the encapsulating material were prepared through a modified water‐in‐oil‐in‐water (W/O/W) emulsification and solvent evaporation method. The average particle size of PLA nanocapsules obtained was decreased to (181.5±8.4) nm, and capably adju...

Full description

Saved in:
Bibliographic Details
Published in:Chinese journal of chemistry 2006-01, Vol.24 (1), p.109-113
Main Authors: Zhu, Yin-Yan, Zhang, Gao-Yong, Hong, Xin-Lin, Dong, Jin-Feng, Xia, Bi-Lai
Format: Article
Language:English
Subjects:
double emulsion
emulsifier
insulin
nanocapsules
polylactide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Insulin entrapped nanocapsules to use polylactide (PLA) as the encapsulating material were prepared through a modified water‐in‐oil‐in‐water (W/O/W) emulsification and solvent evaporation method. The average particle size of PLA nanocapsules obtained was decreased to (181.5±8.4) nm, and capably adjusted from 180 to 370 nm by using different types and content of nonionic emulsifiers. The influence of emulsifiers on property of nanocapsules was discussed in detail. The effects of spans and tweens to modify the size of the nanocapsules were different, which can be due to the distribution of the surfactants on the inner interface between the inner water and oil of the double emulsion. The encapsulation efficiency and drug release of nanocapsules were affected obviously by the content and type of emulsifiers.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.200690003