Efficient Synthesis of β-Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst

Aluminum chloride （AlCl3） efficiently catalyzes one-pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β-acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. More...

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Bibliographic Details
Published in:Chinese journal of chemistry 2012-02, Vol.30 (2), p.345-352
Main Author: Mohammad Ali, Zolfigol Ardeshir, Khazaei Mohammad, Mokhlesi Abdolkarim, Zare Maliheh, Safaiee Fatemeh, Derakhshan-Panah Hassan, Keypour Ahmad, Ali Dehghani-Firouzabadi Maria, Merajoddin
Format: Article
Language:English
Subjects:
AlCl3
aluminum chloride
enolizable ketone
multicomponent reactions
synthetic methods
β-acetamido ester
β-acetamido ketone
乙酰氨基
廉价
氯化铝
绿色催化剂
酮
酯类衍生物
高效合成
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Summary:Aluminum chloride （AlCl3） efficiently catalyzes one-pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β-acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. Moreover, by this synthetic method, some novel β-acetamido ketones and esters （i.e. one complex structure） are prepared.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201180460