Efficient Synthesis of Unsymmetrical Heteroaryl Ethers by a Transition Metal-Free C--O Cross-Coupling Reaction of Activated and Unactivated Heteroaryl Chlorides with Alcohols and Phenols

By optimizing the reaction conditions via a careful screening of the bases and solvents, we developed an efficient transition metal-free method for C--O cross-coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcohols and phenols, providing a simple, efficient, an...

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Bibliographic Details
Published in:Chinese journal of chemistry 2013-06, Vol.31 (6), p.764-772
Main Authors: Liu, Quan, Lu, Zhongxiang, Ren, Wenfei, Shen, Kaibo, Wang, Yu, Xu, Qing
Format: Article
Language:English
Subjects:
alcohols
CO cross coupling
heteroaryl ethers
heteroaryl halides
phenols
transition metal-free
交叉偶联反应
氯化物
激活
芳醚
过渡金属
酚类
醇类
高效合成
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Summary:By optimizing the reaction conditions via a careful screening of the bases and solvents, we developed an efficient transition metal-free method for C--O cross-coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcohols and phenols, providing a simple, efficient, and practical method for synthesis of the useful unsymmetrical heteroaryl alkyl and heteroaryl aryl ethers.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201300120