Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp 3 C—H Bonds with Iodine( III )

A metal‐free, green, and sustainable functionalization of unactivated alkyl sp 3 C—H bonds is reported using iodine(III) as a feasible dehydrogenation agent under visible light or KBr, and alkyl chlorides, bromides, alcohols, and ketones could be constructed by addition of different coupling reagent...

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Bibliographic Details
Published in:Chinese journal of chemistry 2024-03, Vol.42 (5), p.505-510
Main Authors: Jia, Hao, Li, Nan, Tang, Chunmei, Wang, Yajuan, Xi, Yonghao, Liao, Rongbao, Xu, Wei, Wu, Fufang, Shen, Xiaobao, Zhai, Hongbin
Format: Article
Language:English
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Summary:A metal‐free, green, and sustainable functionalization of unactivated alkyl sp 3 C—H bonds is reported using iodine(III) as a feasible dehydrogenation agent under visible light or KBr, and alkyl chlorides, bromides, alcohols, and ketones could be constructed by addition of different coupling reagents. Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp 3 C—H bond in a highly efficient manner, which can construct different alkylation products by adding corresponding coupling reagents.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202300544