Cover Picture: Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics (ChemMedChem 7/2006)

The cover picture shows an electron micrograph of Bacillus subtilis before (inset) and after treatment with an acyldepsipeptide (ADEP, structure shown), which blocks cell division to produce filamented cell structures. Exploration of the synthesis of enopeptin‐type acyldepsipeptide antibiotics has l...

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Bibliographic Details
Published in:ChemMedChem 2006-07, Vol.1 (7), p.661-661
Main Authors: Hinzen, Berthold, Raddatz, Siegfried, Paulsen, Holger, Lampe, Thomas, Schumacher, Andreas, Häbich, Dieter, Hellwig, Veronica, Benet-Buchholz, Jordi, Endermann, Rainer, Labischinski, Harald, Brötz-Oesterhelt, Heike
Format: Article
Language:English
Subjects:
antibiotics
drug resistance
Gram-positive bacteria
structure-activity relationships
Online Access:Get full text
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Summary:The cover picture shows an electron micrograph of Bacillus subtilis before (inset) and after treatment with an acyldepsipeptide (ADEP, structure shown), which blocks cell division to produce filamented cell structures. Exploration of the synthesis of enopeptin‐type acyldepsipeptide antibiotics has led to new compounds with improved in vitro antibiotic activity against Gram‐positive pathogens and in vivo activity in mouse models of lethal infection. For details, see the Communication by B. Hinzen et al. on p. 689 ff.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200690022