Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)benzenesulfonamide Derivatives and Their Antitumor Mechanisms

Breaking the cycle: A series of N‐(2‐arylindol‐7‐yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone‐resistant prostate cancer PC‐3 cells, induced G2/M‐phase arrest, and induced apoptosis through a caspase‐dependent path...

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Bibliographic Details
Published in:ChemMedChem 2010-09, Vol.5 (9), p.1489-1497
Main Authors: Chiou, Chun-Tang, Chen, Grace Shiahuy, Chen, Meng-Ling, Li, Huoming, Shi, Lei, Huang, Xiang-Hong, Dai, Wei-Ming, Chern, Ji-Wang
Format: Article
Language:English
Subjects:
antimitotic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - toxicity
apoptosis
Benzenesulfonamides
Cell Division
Cell Line, Tumor
cytotoxicity
Drug Screening Assays, Antitumor
G2 Phase
Humans
Indoles - chemical synthesis
Indoles - chemistry
Indoles - toxicity
Male
microtubules
Microtubules - chemistry
Microtubules - metabolism
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - metabolism
Structure-Activity Relationship
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Sulfonamides - toxicity
Tubulin Modulators - chemical synthesis
Tubulin Modulators - chemistry
Tubulin Modulators - toxicity
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Summary:Breaking the cycle: A series of N‐(2‐arylindol‐7‐yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone‐resistant prostate cancer PC‐3 cells, induced G2/M‐phase arrest, and induced apoptosis through a caspase‐dependent pathway.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201000228