Cover Picture: Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7 (ChemMedChem 10/2017)

The front cover picture shows the C‐terminal domain of Nucleocapsid Protein 7 (NCp7) of the human immunodeficiency virus (HIV) and the likely mode by which an S‐acetylmercaptobenzamide molecule reacts with the protein. Acetyl transfer from the mercaptobenzamide to the sulfur of a cysteine in NCp7 de...

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Bibliographic Details
Published in:ChemMedChem 2017-05, Vol.12 (10), p.713-713
Main Authors: Saha, Mrinmoy, Scerba, Michael T., Shank, Nathaniel I., Hartman, Tracy L., Buchholz, Caitlin A., Buckheit, Robert W., Durell, Stewart R., Appella, Daniel H.
Format: Article
Language:English
Subjects:
antiviral agents
HIV
mercaptobenzamides
nucleocapsid protein 7
prodrugs
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Summary:The front cover picture shows the C‐terminal domain of Nucleocapsid Protein 7 (NCp7) of the human immunodeficiency virus (HIV) and the likely mode by which an S‐acetylmercaptobenzamide molecule reacts with the protein. Acetyl transfer from the mercaptobenzamide to the sulfur of a cysteine in NCp7 destabilizes the zinc coordination, which leads to protein unfolding and loss of function. These types of molecules are being developed as potential new treatments for HIV infection. More information can be found in the Communication by Daniel H. Appella et al. on page 714 in Issue 10, 2017 (DOI: 10.1002/cmdc.201700141).
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201700283