Front Cover: Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies (ChemMedChem 17/2019)

The Front Cover shows Guineensine in the foreground, a natural product derived from the fruits of black pepper, Piper nigrum, and several other pepper species. Guineensine is a natural uptake inhibitor of endocannabinoids, thereby showing cannabimimetic and also pronounced antiinflammatory effects....

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Bibliographic Details
Published in:ChemMedChem 2019-09, Vol.14 (17), p.1573-1573
Main Authors: Bartholomäus, Ruben, Nicolussi, Simon, Baumann, Alice, Rau, Mark, Simão, Ana Catarina, Gertsch, Jürg, Altmann, Karl‐Heinz
Format: Article
Language:English
Subjects:
endocannabinoid membrane transport
endocannabinoids
guineensine
natural products
total synthesis
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Summary:The Front Cover shows Guineensine in the foreground, a natural product derived from the fruits of black pepper, Piper nigrum, and several other pepper species. Guineensine is a natural uptake inhibitor of endocannabinoids, thereby showing cannabimimetic and also pronounced antiinflammatory effects. The authors devised a total synthesis of Guineensine in five steps. Additionally, they synthesized derivatives of Guineensine for studying structure–activity relationships. Cover picture by Alice Baumann with help from Barth van Rossum (FMP Berlin). Brain picture from Jolygon/shutterstock.com. Background picture of pepper plant from Jürg Gertsch. More information can be found in the Full Paper by Karl‐Heinz Altmann et al. on page 1590 in Issue 17, 2019 (DOI: 10.1002/cmdc.201900390).
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201900490