Enhanced Penetration of Silver Nanocomposite Assemblies into Dentine Using Iontophoresis: Toward the Treatment of Dental Caries

A strategy to prevent and treat tooth decay, which utilises electrophoretic movement of charged, antibacterial silver nanocomposite structures to infiltrate human dentine to target bacteria contained within the dentine tubules, has been developed and evaluated. Scanning electron microscopy and energ...

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Bibliographic Details
Published in:ChemPlusChem (Weinheim, Germany) Germany), 2014-12, Vol.79 (12), p.1671-1675
Main Authors: Schwass, Donald R., Meledandri, Carla J.
Format: Article
Language:English
Subjects:
antibacterial
dental caries
iontophoresis
nanoparticles
silver
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Summary:A strategy to prevent and treat tooth decay, which utilises electrophoretic movement of charged, antibacterial silver nanocomposite structures to infiltrate human dentine to target bacteria contained within the dentine tubules, has been developed and evaluated. Scanning electron microscopy and energy‐dispersive X‐ray spectroscopy have confirmed high affinity of the nanocomposite structures for tooth tissue, and enhanced penetration of the nanostructures into the tubules under the influence of direct current. It is anticipated that this strategy could be used to sterilise dentine prior to the placement of a dental restorative material. A silver bullet? A simple but effective electrophoretic method has been developed for the enhanced delivery and retention of antibacterial silver nanoparticle‐based materials to dentine tubules (see figure). This innovative approach may lead to more successful management of tooth decay, without the corresponding staining effects caused through the use of silver compounds.
ISSN:2192-6506
2192-6506
DOI:10.1002/cplu.201402132