Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells

The concept of gene vectors for therapeutic applications has been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at th...

Full description

Saved in:
Bibliographic Details
Published in:ChemPlusChem (Weinheim, Germany) Germany), 2020-03, Vol.85 (3), p.466-475
Main Authors: Singh, Adhish, Hua Hsu, Ming, Gupta, Neeraj, Khanra, Partha, Kumar, Pankaj, Prakash Verma, Ved, Kapoor, Mohit
Format: Article
Language:English
Subjects:
Animals
carbon nanotubes
Cell Line
Cell Membrane Permeability
Cell Survival - drug effects
delivery systems
gene therapy
Gene Transfer Techniques
Genetic Therapy
Genetic Vectors - chemistry
Genetic Vectors - metabolism
HIV Infections - therapy
Humans
nanotechnology
Nanotubes, Carbon - chemistry
Neoplasms - therapy
Plant Cells - metabolism
Plants
Plasmids - chemistry
Plasmids - metabolism
RNA Interference
Surface Properties
therapeutics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The concept of gene vectors for therapeutic applications has been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at the required site of action in mammalian and plant cells. The ease of diversified functionalization has allowed CNTs to be by far the most adaptable non‐viral vector for gene therapy. This Minireview addresses the dexterity with which CNTs undergo surface modifications and their applications as a potent vector in gene therapy of humans and plants. Specifically, we will discuss the new tools that scientific communities have invented to achieve gene therapy using plasmid DNA, RNA silencing, suicide gene therapy, and plant genetic engineering. Additionally, we will shed some light on the mechanism of gene transportation using carbon nanotubes in cancer cells and plants. In this Minireview, recent developments in the precise tailoring of carbon nanotubes for gene therapy in mammalian and plant cells are summarized. Emphasis has been given to covalent and noncovalent functionalization of nanotubes as effective non‐viral vectors. The ability of nanotubes to transfect cellular barriers is central to their use in gene therapy.
ISSN:2192-6506
2192-6506
DOI:10.1002/cplu.201900678