Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

The development of efficient catalytic systems is a fundamental aspect for the straightforward production of chemicals. During the last years, covalent organic frameworks (COFs) emerged as an exciting class of organic nanoporous materials. Due to their pre‐designable structure, they can be prepared...

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Bibliographic Details
Published in:ChemPlusChem (Weinheim, Germany) Germany), 2020-09, Vol.85 (9), p.2051-2066
Main Authors: Oliveira, Felipe L., S. França, Alexandre, Castro, Aline Machado, Alves de Souza, Rodrigo O. M., Esteves, Pierre M., Gonçalves, Raoni Schroeder B.
Format: Article
Language:English
Subjects:
biocatalysis
covalent organic frameworks
enzymes
heterogeneous catalysis
nanostructures
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Summary:The development of efficient catalytic systems is a fundamental aspect for the straightforward production of chemicals. During the last years, covalent organic frameworks (COFs) emerged as an exciting class of organic nanoporous materials. Due to their pre‐designable structure, they can be prepared with distinct physicochemical characteristics, specific pore sizes, and tunable functional groups. Moreover, associated with their stability in different media, these materials are considered promising supports for enzyme immobilization. Herein, it is highlighted the recent literature of enzyme immobilization in COFs, the main immobilization strategies, and the catalytic applications of these composites. Enzyme immobilization in COFs: Covalent organic frameworks (COFs) are an emergent class of nanomaterials, designed by the covalent bonding of one or more organic building blocks, following the concepts of reticular chemistry. Recent advances of enzyme immobilization in COFs are presented. Important aspects related to the structure, the preparation and characterization of these composites are highlighted, as well as their applications in different areas such as heterogenous catalysis, sensor development and chiral resolution. Future perspectives of this field are also commented.
ISSN:2192-6506
2192-6506
DOI:10.1002/cplu.202000549