Focus on cannabinoids and synthetic cannabinoids

The recent emergence of a multitude of synthetic cannabinoids (SCs) has generated a wealth of new information, suggesting the usefulness of state‐of‐the‐art on lato sensu cannabinoids. By modulating a plurality of neurotransmission pathways, the endocannabinoid system is involved in many physiologic...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2017-02, Vol.101 (2), p.220-229
Main Authors: Le Boisselier, R, Alexandre, J, Lelong‐Boulouard, V, Debruyne, D
Format: Article
Language:English
Subjects:
Cannabinoids - chemistry
Cannabinoids - pharmacokinetics
Cannabinoids - pharmacology
Cardiovascular System - drug effects
Central Nervous System Diseases - drug therapy
Designer Drugs - chemistry
Designer Drugs - pharmacokinetics
Designer Drugs - pharmacology
Endocannabinoids
Enteric Nervous System - drug effects
Eye - drug effects
Eye Diseases - drug therapy
GABAergic Neurons - metabolism
Humans
Kidney - drug effects
Marijuana Abuse - epidemiology
Marijuana Abuse - mortality
Medical Marijuana - therapeutic use
Pain Management - methods
Quantitative Structure-Activity Relationship
Receptor, Cannabinoid, CB1 - metabolism
Receptor, Cannabinoid, CB2 - metabolism
Receptors, Cannabinoid - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Substance Withdrawal Syndrome - physiopathology
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Summary:The recent emergence of a multitude of synthetic cannabinoids (SCs) has generated a wealth of new information, suggesting the usefulness of state‐of‐the‐art on lato sensu cannabinoids. By modulating a plurality of neurotransmission pathways, the endocannabinoid system is involved in many physiological processes that are increasingly explored. SCs desired and adverse effects are considered to be more intense than those observed with cannabis smoking, which is partly explained by the full agonist activity and higher affinity for cannabinoid receptors. Neurological and cardiovascular side effects observed after cannabinoid poisoning generally respond to conventional supportive care, but severe outcomes may occur in a minority of cases, mainly observed with SCs. The likelihood of severe abuse and addiction produced by SCs are of concern for the scientific community also interested in the potential therapeutic value of cannabinoids.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.563