Pro‐Hepcidin Levels in Peritoneal Dialysis and Hemodialysis Patients

OBJECTIVE Anemia is a major clinical problem in patients receiving dialysis therapy and has a substantial impact on morbidity and mortality. Iron metabolism is impaired in chronic kidney disease. Hepcidin functions as a key regulator of iron metabolism. The aims of this study were to compare the ser...

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Bibliographic Details
Published in:Dialysis & transplantation 2009-06, Vol.38 (6), p.203-209
Main Authors: Turgut, Faruk, Kanbay, Mehmet, Altay, Mustafa, Uz, Ebru, Bavbek, Nuket, Koca, Cemile, Secilmis, Sema, Duranay, Murat, Akcay, Ali, Covic, Adrian
Format: Article
Language:English
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Summary:OBJECTIVE Anemia is a major clinical problem in patients receiving dialysis therapy and has a substantial impact on morbidity and mortality. Iron metabolism is impaired in chronic kidney disease. Hepcidin functions as a key regulator of iron metabolism. The aims of this study were to compare the serum pro‐hepcidin levels in patients with either peritoneal dialysis (PD) or hemodialysis (HD) and control subjects and to evaluate pro‐hepcidin and C‐reactive protein (CRP), iron parameters, and hemoglobin levels in PD and HD patients with normal serum CRP levels. METHODS We studied 85 PD patients, 43 HD patients on regular follow‐up, and a control group that was comprised of 41 volunteers in this cross‐sectional study. Pro‐hepcidin and CRP were studied using commercially available kits. Iron status was assessed by measuring serum iron, transferrin saturation, and ferritin. RESULTS Pro‐hepcidin levels were significantly higher in dialysis patients than the control subjects (p 
ISSN:0090-2934
1932-6920
DOI:10.1002/dat.20297