Upregulation of proteinase-activated receptors (PARs) and cardiovascular function

Proteinase activated receptors (PARs) have attracted particular attention for their possible role in cardiovascular physiology and disease. The aim of this article is to review what is known up to now about the upregulation of PARs that are targets for thrombin (PARs 1, 3, and 4) and PAR2, which is...

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Bibliographic Details
Published in:Drug development research 2003-09, Vol.60 (1), p.20-23
Main Authors: Cirino, Giuseppe, Cicala, Carla
Format: Article
Language:English
Subjects:
cardiovascular
proteinases
upregulation
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Summary:Proteinase activated receptors (PARs) have attracted particular attention for their possible role in cardiovascular physiology and disease. The aim of this article is to review what is known up to now about the upregulation of PARs that are targets for thrombin (PARs 1, 3, and 4) and PAR2, which is not activated by thrombin. Particular emphasis will be given to what is the “state of the art” on the upregulation of these receptors within the cardiovascular system and their relationship to those phenomena that can be encompassed under the term “cardiovascular inflammation.“ Drug Dev. Res. 60:20–23, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.10315