B ReDi mouse: A novel transgenic mouse strain to track and deplete B cells

B mice express a red fluorescent protein together with the diphtheria toxin receptor selectively in B cells. B cells can be effectively visualized by red fluorescence and can be efficiently depleted in a highly controlled fashion to study their functional capacity in vivo.

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Bibliographic Details
Published in:European journal of immunology 2019-03, Vol.49 (3), p.500-503
Main Authors: Mues, Marsilius, Krishnamoorthy, Gurumoorthy
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell Tracking - methods
Diphtheria Toxin - administration & dosage
Diphtheria Toxin - metabolism
Heparin-binding EGF-like Growth Factor - genetics
Heparin-binding EGF-like Growth Factor - metabolism
Humans
Injections, Intraperitoneal
Luminescent Proteins - genetics
Luminescent Proteins - metabolism
Lymphocyte Depletion - methods
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Confocal
Microscopy, Fluorescence
Red Fluorescent Protein
Time-Lapse Imaging - methods
Citations: Items that this one cites
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Description
Summary:B mice express a red fluorescent protein together with the diphtheria toxin receptor selectively in B cells. B cells can be effectively visualized by red fluorescence and can be efficiently depleted in a highly controlled fashion to study their functional capacity in vivo.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201847930