Ruthenium Tetraammines as a Model of Nitric Oxide Donor Compounds

The nitric oxide liberation from trans‐[Ru(NH3)4(L)(NO)]3+ (where L = py, 4‐pic, isn, nic, L‐His, 4‐Clpy, imN) after one‐electron‐chemical or electrochemical reduction was investigated through spectroscopic and electrochemical techniques, reaction‐product analysis and quantum‐mechanic calculations....

Full description

Saved in:
Bibliographic Details
Published in:European journal of inorganic chemistry 2004-05, Vol.2004 (9), p.1879-1885
Main Authors: Toledo, José Carlos, Silva, Hildo A. S., Scarpellini, Marciela, Mori, Vânia, Camargo, Ademir J., Bertotti, Mauro, Franco, Douglas W.
Format: Article
Language:English
Subjects:
N-heterocyclic ligands
Nitric oxide
NO donor
Ruthenium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The nitric oxide liberation from trans‐[Ru(NH3)4(L)(NO)]3+ (where L = py, 4‐pic, isn, nic, L‐His, 4‐Clpy, imN) after one‐electron‐chemical or electrochemical reduction was investigated through spectroscopic and electrochemical techniques, reaction‐product analysis and quantum‐mechanic calculations. These complexes can be formally viewed as a RuII(NO+) species and the reduction site is located on the NO ligand. The E° for the trans‐[RuII(NH3)4(L)(NO+)]3+/trans‐[RuII(NH3)4(L)(NO)]2+ redox process ranges from 0.072 V vs. NHE (nic) to −0.118 V vs. NHE (imN). The specific rate constants for NO dissociation from trans‐[RuII(NH3)4(L)(NO)]2+, evaluated through double‐step chronoamperometry, range from 0.025 s−1 (nic) to 0.160 s−1 (ImN) at 25 °C. The [RuIINO+/RuIINO0] redox potential and the specific rate constant (k‐NO),key steps for designing nitrosyl complexes as NO‐donor drug prototypes, proved to be controlled by a judicious choice of the ligand (L) trans to NO. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.200300683