Physical Properties of Eu 2+ ‐Containing Cryptates as Contrast Agents for Ultrahigh‐Field Magnetic Resonance Imaging

The kinetic stabilities and relaxivities of a series of Eu 2+ ‐containing cryptates have been investigated. Transmetallation studies, which monitored the change in the longitudinal relaxation rate of water protons in the presence of Ca 2+ , Mg 2+ , and Zn 2+ , demonstrated that the cryptate structur...

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Bibliographic Details
Published in:European journal of inorganic chemistry 2012-04, Vol.2012 (12), p.2135-2140
Main Authors: Garcia, Joel, Kuda‐Wedagedara, Akhila N. W., Allen, Matthew J.
Format: Article
Language:English
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Summary:The kinetic stabilities and relaxivities of a series of Eu 2+ ‐containing cryptates have been investigated. Transmetallation studies, which monitored the change in the longitudinal relaxation rate of water protons in the presence of Ca 2+ , Mg 2+ , and Zn 2+ , demonstrated that the cryptate structure influenced the stability, and two of the cryptates studied were inert to transmetallation in the presence of these endogenous ions. The efficacy of these cryptates was determined at different magnetic field strengths, temperatures, and pH values. Cryptate relaxivity was found to be higher at ultrahigh field strengths (7 and 9.4 T) relative to clinically relevant field strengths (1.4 and 3 T), but the efficiency of these cryptates decreased as the temperature increased. In addition, a variation in pH did not yield significant changes in the efficacy of the cryptates. These studies establish a foundation of important properties that are necessary to develop effective positive contrast agents for magnetic resonance imaging from Eu 2+ ‐containing cryptates.
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.201101166