Supplementation of tocotrienol-rich fraction increases interferon-gamma production in ovalbumin-immunized mice

Palm oil is a rich source of vitamin E. The tocotrienol-rich fraction (TRF) extracted from palm oil contain 70% tocotrienols and 30% tocopherols. The effect of TRF supplementation on the immune modulation was evaluated in 6-wk-old female BALB/c mice immunized with ovalbumin (OVA) adjuvanted with alu...

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Published in:European journal of lipid science and technology 2010-05, Vol.112 (5), p.531-536
Main Authors: Nesaretnam, Kalanithi, Mahalingam, Dashayini, Radhakrishnan, Ammu Kutty, Premier, Robert
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fat industries
Feeding. Feeding behavior
Food industries
Fundamental and applied biological sciences. Psychology
Interferon-gamma
Ovalbumin
Tocotrienol-rich fraction
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin E
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container_title European journal of lipid science and technology
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creator Nesaretnam, Kalanithi
Mahalingam, Dashayini
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Premier, Robert
description Palm oil is a rich source of vitamin E. The tocotrienol-rich fraction (TRF) extracted from palm oil contain 70% tocotrienols and 30% tocopherols. The effect of TRF supplementation on the immune modulation was evaluated in 6-wk-old female BALB/c mice immunized with ovalbumin (OVA) adjuvanted with alum. Mice in control and experimental groups were immunized subcutaneously (s.c.) on days 14 and 28 with a single dose of 50 μg OVA. The mice in the experimental group were orally gavaged daily with 1 mg of TRF from palm oil while those in the control group received carrier oil. The results show that mice in the experimental group produced significantly (p0.05) difference in the levels of interleukin-4 (IL-4) produced between the control and experimental animals. Lymphocyte proliferation in response to mitogen or OVA stimulation was significantly (p
doi_str_mv 10.1002/ejlt.200900193
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The tocotrienol-rich fraction (TRF) extracted from palm oil contain 70% tocotrienols and 30% tocopherols. The effect of TRF supplementation on the immune modulation was evaluated in 6-wk-old female BALB/c mice immunized with ovalbumin (OVA) adjuvanted with alum. Mice in control and experimental groups were immunized subcutaneously (s.c.) on days 14 and 28 with a single dose of 50 μg OVA. The mice in the experimental group were orally gavaged daily with 1 mg of TRF from palm oil while those in the control group received carrier oil. The results show that mice in the experimental group produced significantly (p&lt;0.05) higher levels of interferon-gamma (IFN-γ) compared to the control group. There was no significant (p&gt;0.05) difference in the levels of interleukin-4 (IL-4) produced between the control and experimental animals. Lymphocyte proliferation in response to mitogen or OVA stimulation was significantly (p&lt;0.05) higher in splenocytes derived from the TRF supplemented mice compared to control mice. These findings show that daily supplementation of palm TRF can induce a strong cell-mediated immune response, i.e., T-helper-1 (Th1) response, which would be beneficial to fight viral infections and cancer.</description><identifier>ISSN: 1438-7697</identifier><identifier>EISSN: 1438-9312</identifier><identifier>DOI: 10.1002/ejlt.200900193</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>Biological and medical sciences ; Fat industries ; Feeding. Feeding behavior ; Food industries ; Fundamental and applied biological sciences. 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Lymphocyte proliferation in response to mitogen or OVA stimulation was significantly (p&lt;0.05) higher in splenocytes derived from the TRF supplemented mice compared to control mice. These findings show that daily supplementation of palm TRF can induce a strong cell-mediated immune response, i.e., T-helper-1 (Th1) response, which would be beneficial to fight viral infections and cancer.</description><subject>Biological and medical sciences</subject><subject>Fat industries</subject><subject>Feeding. Feeding behavior</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Interferon-gamma</topic><topic>Ovalbumin</topic><topic>Tocotrienol-rich fraction</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nesaretnam, Kalanithi</creatorcontrib><creatorcontrib>Mahalingam, Dashayini</creatorcontrib><creatorcontrib>Radhakrishnan, Ammu Kutty</creatorcontrib><creatorcontrib>Premier, Robert</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>European journal of lipid science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nesaretnam, Kalanithi</au><au>Mahalingam, Dashayini</au><au>Radhakrishnan, Ammu Kutty</au><au>Premier, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation of tocotrienol-rich fraction increases interferon-gamma production in ovalbumin-immunized mice</atitle><jtitle>European journal of lipid science and technology</jtitle><addtitle>Eur. 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subjects Biological and medical sciences
Fat industries
Feeding. Feeding behavior
Food industries
Fundamental and applied biological sciences. Psychology
Interferon-gamma
Ovalbumin
Tocotrienol-rich fraction
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin E
title Supplementation of tocotrienol-rich fraction increases interferon-gamma production in ovalbumin-immunized mice
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