Investigations into the Regioselective C-Deuteration of Acyclic and Exocyclic Enolates

Results are reported on the regioselective C‐deuteration of a series of related acyclic and exocyclic enolates derived from substituted aryl ketones. We comment on factors, such as the presence of additives and the structural nature of the enolate, that influence the observed C‐deuteration and discu...

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Bibliographic Details
Published in:European journal of organic chemistry 2003-02, Vol.2003 (4), p.634-641
Main Authors: Eames, Jason, Coumbarides, Gregory S., Suggate, Michael J., Weerasooriya, Neluka
Format: Article
Language:English
Subjects:
Deuterium
Isotopic labeling
Ketones
Kinetic deuteration
Lithium
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Summary:Results are reported on the regioselective C‐deuteration of a series of related acyclic and exocyclic enolates derived from substituted aryl ketones. We comment on factors, such as the presence of additives and the structural nature of the enolate, that influence the observed C‐deuteration and discuss the role of the deuterium donor. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200390103