A Short and Efficient Synthetic Strategy for the Total Syntheses of (S)-(+)- and (R)-(-)-Plakolide A

Concise and efficient total syntheses of anticancer agents (S)‐(+)‐Plakolide A and (R)‐(–)‐Plakolide A were accomplished in eight steps and an overall yield of 39 % starting from geraniol. The key steps in our strategy are Sharpless asymmetric epoxidation, double elimination, and Stille coupling rea...

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Bibliographic Details
Published in:European Journal of Organic Chemistry 2007-10, Vol.2007 (30), p.5059-5063
Main Authors: Mohapatra, Debendra K., Pramanik, Chinmoy, Chorghade, Mukund S., Gurjar, Mukund K.
Format: Article
Language:English
Subjects:
Cross-coupling
Epoxidation
Inhibitors
Olefination
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Summary:Concise and efficient total syntheses of anticancer agents (S)‐(+)‐Plakolide A and (R)‐(–)‐Plakolide A were accomplished in eight steps and an overall yield of 39 % starting from geraniol. The key steps in our strategy are Sharpless asymmetric epoxidation, double elimination, and Stille coupling reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200700401