The Creolophins: A Family of Linear Triquinanes from Creolophus cirrhatus (Basidiomycete)

Complicatic acid and five novel linear triquinanes were isolated from mycelial cultures of Creolophus cirrhatus. The creolophins A, C, D, and E represent a novel type of highly oxidized triquinane sesquiterpenoids. Whereas those compounds with a secondary alcohol moiety in ring A are stable, the exo...

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Bibliographic Details
Published in:European Journal of Organic Chemistry 2007-11, Vol.2007 (33), p.5546-5550
Main Authors: Opatz, Till, Kolshorn, Heinz, Birnbacher, Judith, Schüffler, Anja, Deininger, Friederike, Anke, Timm
Format: Article
Language:English
Subjects:
Natural products
NMR spectroscopy
Structure elucidation
Terpenoids
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Summary:Complicatic acid and five novel linear triquinanes were isolated from mycelial cultures of Creolophus cirrhatus. The creolophins A, C, D, and E represent a novel type of highly oxidized triquinane sesquiterpenoids. Whereas those compounds with a secondary alcohol moiety in ring A are stable, the exomethylene ketone creolophin E (5) partly dimerized during workup to form the decacyclic 1,4‐dioxepin‐6‐one neocreolophin (6). Compounds 5 and 6 display cytotoxic activities against several tumor cell lines.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200700555