Transition Metal-Catalyzed Formation of N-Heterocycles via Aryl- or Vinyl C-H Bond Amination

The construction of N‐heterocycles remains a fertile area of research because of their ubiquitous occurrence in biologically active small molecules and materials. Their ubiquitous nature has motivated the development of methods to streamline their synthesis. Formation of the C–N bond via transition...

Full description

Saved in:
Bibliographic Details
Published in:European Journal of Organic Chemistry 2011-08, Vol.2011 (22), p.4071-4088
Main Authors: Stokes, Benjamin J., Driver, Tom G.
Format: Article
Language:English
Subjects:
Amination
C-H activation
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Homogeneous catalysis
Kinetics and mechanisms
Nitrogen heterocycles
Organic chemistry
Preparations and properties
Reactivity and mechanisms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The construction of N‐heterocycles remains a fertile area of research because of their ubiquitous occurrence in biologically active small molecules and materials. Their ubiquitous nature has motivated the development of methods to streamline their synthesis. Formation of the C–N bond via transition metal‐functionalization of the aryl or vinyl C–H bond simplifies N‐heterocycle synthesis by minimizing the manipulation of functional groups. Transition metal‐catalyzed C–H bond amination can be accomplished through two strategies: the activation of the N‐atom or activation of the C–H bond. This microreview examines the recent advances in applying these two strategies for the functionalization of sp2 C–H bonds and is organized by the source of nitrogen atom. This microreview describes the recent advances in transition metal‐catalyzed sp2 C–H bond amination reactions.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201100150