Cu II ‐Promoted Aerobic Cascade Reactions of 2‐Alkynylanilines with Methyl Perfluoroalk‐2‐ynoates: En Route to 4‐Carbonyl‐2‐perfluoroalkylquinolines

Using air as the oxygen source, 4‐carbonyl‐2‐perfluoroalkylquinolines were prepared in good to excellent yields, from readily available 2‐alkynylanilines and methyl perfluoroalk‐2‐ynoates through a Cu II ‐promoted sequential process that omits the isolation of the enamine intermediates. The reaction...

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Bibliographic Details
Published in:European journal of organic chemistry 2015-03, Vol.2015 (9), p.2061-2065
Main Authors: Han, Jing, Shen, Yangyong, Sun, Xuechun, Yao, Qiuxia, Chen, Jie, Deng, Hongmei, Shao, Min, Fan, Bozhen, Zhang, Hui, Cao, Weiguo
Format: Article
Language:English
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Summary:Using air as the oxygen source, 4‐carbonyl‐2‐perfluoroalkylquinolines were prepared in good to excellent yields, from readily available 2‐alkynylanilines and methyl perfluoroalk‐2‐ynoates through a Cu II ‐promoted sequential process that omits the isolation of the enamine intermediates. The reaction tolerates several useful functionalities including ether, ester and chloro substituents.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201403633