Cover Feature: One‐Pot Two‐Step Chemoenzymatic Cascade for the Synthesis of a Bis‐benzofuran Derivative (Eur. J. Org. Chem. 37/2019)

The Cover Feature shows two gearwheels interlocking, symbolizing the key principle of the cascade reaction. The bottom gearwheel depicts Sonogashira cross‐coupling initiated by a Cu scorpionate to synthesize a 2‐substituted benzofuran derivative. The top gearwheel illustrates the P450 BM3 catalyzed...

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Bibliographic Details
Published in:European journal of organic chemistry 2019-10, Vol.2019 (37), p.6307-6307
Main Authors: Mertens, M. A. Stephanie, Thomas, Fabian, Nöth, Maximilian, Moegling, Julian, El‐Awaad, Islam, Sauer, Daniel F., Dhoke, Gaurao V., Xu, Wenjing, Pich, Andrij, Herres‐Pawlis, Sonja, Schwaneberg, Ulrich
Format: Article
Language:English
Online Access:Get full text
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Summary:The Cover Feature shows two gearwheels interlocking, symbolizing the key principle of the cascade reaction. The bottom gearwheel depicts Sonogashira cross‐coupling initiated by a Cu scorpionate to synthesize a 2‐substituted benzofuran derivative. The top gearwheel illustrates the P450 BM3 catalyzed formation to N,N'‐bis(benzofuran‐2‐ylmethyl)‐N,N'‐dimethylmethandiamine. This chemoenzymatic reaction sequence takes advantage of the transition metal catalysis engaged with enzymatic catalysis to synthesize new valuable compounds. More information can be found in the Full Paper by A. Pich, S. Herres‐Pawlis, U. Schwaneberg et al.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201901373