Cover Feature: One‐Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α‐Aryl‐α‐Trifluoromethyl Alcohols (Eur. J. Org. Chem. 29/2020)

The Cover Feature shows a novel straightforward one‐pot synthetic methodology involving two successive reactions of the turbo Grignard reagent for the synthesis of α‐aryl or α‐heteroaryl‐α‐trifluoromethyl alcohols, motifs of value in pharmaceutical chemistry. The method displayed broad functional gr...

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Bibliographic Details
Published in:European journal of organic chemistry 2020-08, Vol.2020 (29), p.4434-4434
Main Authors: Kani, Ryunosuke, Inuzuka, Toshiyasu, Kubota, Yasuhiro, Funabiki, Kazumasa
Format: Article
Language:English
Online Access:Get full text
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Summary:The Cover Feature shows a novel straightforward one‐pot synthetic methodology involving two successive reactions of the turbo Grignard reagent for the synthesis of α‐aryl or α‐heteroaryl‐α‐trifluoromethyl alcohols, motifs of value in pharmaceutical chemistry. The method displayed broad functional group tolerance, including reducible groups. The arrow highlights the rapid synthesis of the desired trifluoromethyl alcohols from commercial available chemicals. More information can be found in the Communication by K. Funabiki et al.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202001036