Access to Pyrrolocoumarins through DBU‐Mediated Coupling of 2‐Oxo‐2 H ‐chromene‐3‐carbaldehydes and Phenacyl Azides

1,8‐Diazabicyclo [5.4.0]undec‐7‐ene (DBU) mediated annulation of 4‐(benzylthio/arylthio)‐2‐oxo‐2 H ‐chromene‐3‐carbaldehydes with phenacyl azides for the synthesis of biologically relevant pyrrolocoumarins was developed. This operationally simple and unique synthetic strategy allows the formation of...

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Bibliographic Details
Published in:European journal of organic chemistry 2022-01, Vol.2022 (2)
Main Authors: Borkotoky, Lodsna, Borra, Satheesh, Maurya, Ram Awatar
Format: Article
Language:English
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Summary:1,8‐Diazabicyclo [5.4.0]undec‐7‐ene (DBU) mediated annulation of 4‐(benzylthio/arylthio)‐2‐oxo‐2 H ‐chromene‐3‐carbaldehydes with phenacyl azides for the synthesis of biologically relevant pyrrolocoumarins was developed. This operationally simple and unique synthetic strategy allows the formation of desired pyrrolocoumarin in good yields (67‐84 %), and generates a new C−C and C−N bond in the overall process.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202101237