Effects of Redox Couple on the Response of Polypyrrole-Based Electrochemical DNA Sensors

Much research‐to‐date exists to create sensitive and selective DNA sensors. A variety of approaches are adopted, including those involving polypyrrole and electrical impedance spectroscopy. Combined these are able to sense as well as aptly transduce signals. Many such sensors employ ferri/ferrocyani...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2012-06, Vol.24 (6), p.1311-1317
Main Authors: Booth, Marsilea Adela, Harbison, SallyAnn, Travas-Sejdic, Jadranka
Format: Article
Language:English
Subjects:
DNA sensors
Electrical impedance spectroscopy
Ferricyanide
Hydroquinone
Polypyrrole
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Summary:Much research‐to‐date exists to create sensitive and selective DNA sensors. A variety of approaches are adopted, including those involving polypyrrole and electrical impedance spectroscopy. Combined these are able to sense as well as aptly transduce signals. Many such sensors employ ferri/ferrocyanide to exhibit surface hybridization. This redox reporter, though with merits, can prove disadvantageous. To this end, a comparative study was performed with the redox reporter hydroquinone. For comparison purposes ferri/ferrocyanide indicated greater sensitivity, suggested to arise from inherent charge. Conversely, with hydroquinone steric hindrance is the main influencing factor. Such a study aims to guide design of analogous sensors.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201200119