Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

• Published in: Electroanalysis (New York, N.Y.) N.Y.), 2019-10, Vol.31 (10), p.1845-1867
• Main Authors: De la Cruz Morales, K., Alarcón‐Angeles, G., Merkoçi, A.
• Format: Article
• Language: English
• Subjects: Biosensing; DNA-electroanalysis; drug-DNA; drug-DNA interaction; Nanomaterials
• ISSN: 1040-0397; 1521-4109
• DOI: 10.1002/elan.201900286

The interaction of drugs with DNA has been searched thoroughly giving rise to an endless number of findings of undoubted importance, such as a prompt alert to harmful substances, ability to explain most of the biological mechanisms, or provision of important clues in targeted development of novel chemotherapeutics. The existence of some drugs that induce oxidative damage is an increasing point of concern as they can cause cellular death, aging, and are closely related to the development of many diseases. Because of a direct correlation between the response, strength/ nature of the interaction and the pharmaceutical action of DNA‐targeted drugs, the electrochemical analysis is based on the signals of DNA before and after the interaction with the DNA‐targeted drug. Nowadays, nanoscale materials are used extensively for offering fascinating characteristics that can be used in designing new strategies for drug‐DNA interaction detection. This work presents a review of nanomaterials (NMs) for the study of drug‐nucleic acid interaction. We summarize types of drug‐DNA interactions, electroanalytical techniques for evidencing these interactions and quantification of drug and/or DNA monitoring.