Screening of Synthetic Cathinones by Potentiometric Sensor Array and Chemometrics

This work demonstrates the analytical applicability of single ion‐selective membranes (ISMs) and potentiometric sensor array to distinguish and detect cathinone derivatives. Potentiometric data from ISMs based on cation exchanger and varying content of calix[4]arene derivative were processed by prin...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2022-07, Vol.34 (7), p.1193-1200
Main Authors: Shishkanova, Tatiana V., Pospíšilová, Eva, Prokopec, Vadim
Format: Article
Language:English
Subjects:
PCA
Potentiometry
Saliva
Synthetic cathinones
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Summary:This work demonstrates the analytical applicability of single ion‐selective membranes (ISMs) and potentiometric sensor array to distinguish and detect cathinone derivatives. Potentiometric data from ISMs based on cation exchanger and varying content of calix[4]arene derivative were processed by principal component analysis (PCA). Such a combination of methods allowed discriminating various individual synthetic cathinones and their recognition from the mixture comprising primary amines (substituted amphetamines+aminoindane). Analytical parameters of ISM containing 1wt % of calix[4]arene derivative were sufficient to detect 1.0×10−4 mol.l−1 1‐(4‐fluorophenyl)‐2‐(ethylamino)butan‐1‐one and 2‐(methylamino)‐1‐phenylbutan‐1‐one (buphedrone) in both model and saliva samples.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.202100483