A Novel Nanoparticles‐based Electrochemical Sensing Platform for Sensitive Detection of Oral Anticoagulant; Edoxaban in Human Plasma

During COVID‐19 pandemic, coagulopathy have been reported as a potential threat to most infected patients. Edoxaban (EDX) is a direct oral anticoagulant that is recently added to most COVID‐19 treatment protocols either as therapy or prophylaxis. Herein, a novel nanoparticles modified glassy carbon...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2022-08, Vol.34 (8), p.1266-1272
Main Authors: Ayish, Nada S., Marzouk, Hoda M., El‐Zeany, Badr A., Fayed, Ahmed S.
Format: Article
Language:English
Subjects:
COVID-19
Anticoagulants
Edoxaban
Glassy carbon electrode
Multiwall carbon nanotubes
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Summary:During COVID‐19 pandemic, coagulopathy have been reported as a potential threat to most infected patients. Edoxaban (EDX) is a direct oral anticoagulant that is recently added to most COVID‐19 treatment protocols either as therapy or prophylaxis. Herein, a novel nanoparticles modified glassy carbon potentiometric sensor was developed for the selective quantitation of EDX in human plasma. The electrochemical performance of the proposed sensor was assessed and compared to nanoparticle free sensor. An enhancement in electrode performance including: detection limit (3.39×10−6 mol L−1), response time (8.0±2.0 s) and improved selectivity. The proposed sensor was able to determine EDX in pure form, pharmaceutical formulation and human plasma.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.202100644