Development of Electroanalytical Methods Using Different Electrodes for the Determination of Progesterone (P4) in Pharmaceutical Formulations and Human, Cow and Goat Milk

For the determination of progesterone (P4) electroanalytical studies were performed using mercury electrode (HMDE) and screen‐printed boron‐doped diamond electrode (BDD‐SPE). The effects of pH, supporting electrolyte, accumulation potential and time (Eacc, tacc) were studied in both systems. The opt...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2023-03, Vol.35 (3), p.n/a
Main Authors: Cruz, Victoria, Triviño, Juan José, Arancibia, Verónica
Format: Article
Language:English
Subjects:
BDD-SPE
HMDE
Milk samples
Pharmaceutical formulations (Progendo®, Progest®, Progeffik®)
Progesterone (P4)
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Summary:For the determination of progesterone (P4) electroanalytical studies were performed using mercury electrode (HMDE) and screen‐printed boron‐doped diamond electrode (BDD‐SPE). The effects of pH, supporting electrolyte, accumulation potential and time (Eacc, tacc) were studied in both systems. The optimum conditions were: i) HMDE: pH 7,0; Eacc: −0,1 V and tacc: 40 s, ii) BDD‐SPE: 0,5 mol L−1 H2SO4; Eacc: 0,0 V and tacc: 120 s. Under these conditions, the detection limit was 3.1 μg L−1 for HMDE and 45.6 μg L−1 for BDD‐SPE. Both methods were validated and applied in the P4 determination on pharmaceutical formulations and milk samples.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.202200272