Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp-based and laser-induced fluorescence detection

Commercial capillary electrophoresis instrumentation with XeHg lamp‐based and laser induced fluorescence (LIF) detection is employed for analysis of urinary 3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy) and its major metabolites, urinary metabolites of acetylsalicylic acid, urinary benzoylecgoni...

Full description

Saved in:
Bibliographic Details
Published in:Electrophoresis 2004-06, Vol.25 (10-11), p.1623-1631
Main Authors: Caslavska, Jitka, Thormann, Wolfgang
Format: Article
Language:English
Subjects:
Albendazole
Albendazole - analogs & derivatives
Albendazole - analysis
Albendazole - blood
Aspirin - analysis
Aspirin - urine
Body Fluids - chemistry
Capillary electrophoresis
Cocaine
Cocaine - analogs & derivatives
Cocaine - analysis
Cocaine - urine
Ecstasy
Electrophoresis, Capillary - instrumentation
Lamp-based fluorescence
Laser-induced fluorescence
Lasers
N-Methyl-3,4-methylenedioxyamphetamine - analysis
N-Methyl-3,4-methylenedioxyamphetamine - urine
Salicylate
Spectrometry, Fluorescence - instrumentation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Commercial capillary electrophoresis instrumentation with XeHg lamp‐based and laser induced fluorescence (LIF) detection is employed for analysis of urinary 3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy) and its major metabolites, urinary metabolites of acetylsalicylic acid, urinary benzoylecgonine in an immunoassay format, and albendazole sulfoxide and albendazole sulfone in plasma. For the examples studied, the data suggest that the lamp‐based detector can be employed for the monitoring of pharmacological and toxicological relevant solute concentrations, and thus represents an attractive alternative to LIF detection.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.200305821