Genetic diversity and haplotype structure of 24 Y ‐chromosomal STR in C hinese H ui ethnic group and its genetic relationships with other populations

• Published in: Electrophoresis 2014-07, Vol.35 (14), p.1993-2000
• Main Authors: Zhu, Bo‐Feng, Zhang, Yu‐Dang, Liu, Wen‐Juan, Meng, Hao‐Tian, Yuan, Guo‐Lian, Lv, Zhe, Dong, Nan, Li, Qiong, Yang, Chun‐hua, Zhang, Yu‐Hong, Hou, Yin‐Ling, Qian, Li, Fan, Shuan‐Liang, Xu, Peng
• Format: Article
• Language: English
• ISSN: 0173-0835; 1522-2683
• DOI: 10.1002/elps.201300574

In the present study, 24 Y ‐chromosomal short tandem repeat ( Y ‐ STR ) loci were analyzed in 115 unrelated H ui male individuals from H aiyuan county or T ongxin county, N ingxia Hui Autonomous Region, C hina, to evaluate the forensic application of the 24 STR loci and to analyze interpopulation differentiations by making comparisons between the H ui group data and previously published data of other 13 populations. A total of 115 different haplotypes were observed on these 24 Y ‐ STR loci. The gene diversities ranged from 0.4049 ( DYS 437) to 0.9729 ( DYS 385a, b). The overall haplotype diversity was 1 at AGCU 24 Y‐ STR loci level, while the values were reduced to 0.999237, 0.996949, and 0.996644 at the Y‐filer 17 loci, 11 Y‐ STR loci of extended haplotype and 9 Y‐ STR loci of minimal haplotype levels, respectively; whereas, haplotype diversity for additional 7 loci (not included in Y‐filer 17 loci) was 0.995271. The pairwise F ST , multidimensional scaling plot and neighbor‐joining tree indicated the Hui group had the closest genetic relationship with Sala in the paternal lineage in the present study. In summary, the results in our study indicated the 24 Y‐ STR s had a high level of polymorphism in H ui group and hence could be a powerful tool for forensic application and population genetic study.