Genome-wide analysis of genetic changes in intestinal-type sinonasal adenocarcinoma

Background Intestinal‐type sinonasal adenocarcinomas are rare tumors related to professional exposure to wood dust. Little is known about the genetic changes in these tumors. Methods Twenty‐two tumors were analyzed by microarray comparative genomic hybridization (CGH). In addition, DNA ploidy was me...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2009-03, Vol.31 (3), p.290-297
Main Authors: Hermsen, Mario A., Llorente, José Luis, Pérez-Escuredo, Jhudit, López, Fernando, Ylstra, Bauke, Álvarez-Marcos, César, Suárez, Carlos
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Aged
Aged, 80 and over
Biological and medical sciences
Chromosome Aberrations
DNA ploidy
Dust
ethmoid sinus
Flow Cytometry
Gene Expression Regulation, Neoplastic
Humans
Male
Medical sciences
microarray CGH
Microsatellite Instability
Middle Aged
Nucleic Acid Hybridization
Oligonucleotide Array Sequence Analysis
Otorhinolaryngology. Stomatology
Paranasal Sinus Neoplasms - genetics
Paranasal Sinus Neoplasms - mortality
Paranasal Sinus Neoplasms - pathology
Ploidies
Polymerase Chain Reaction
Prospective Studies
sinonasal adenocarcinoma
Wood - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Intestinal‐type sinonasal adenocarcinomas are rare tumors related to professional exposure to wood dust. Little is known about the genetic changes in these tumors. Methods Twenty‐two tumors were analyzed by microarray comparative genomic hybridization (CGH). In addition, DNA ploidy was measured by flow cytometry and microsatellite instability (MSI) by multiplex PCR. Results The most frequent gains were, in descending order, as follows: 5p15, 20q13, and 8q24. Losses occurred most frequently at 4q31‐qter, 18q12‐22, 8p12‐pter, and 5q11‐qter. MSI was not detected. Seven cases that harbored very few changes were mostly DNA diploid and had more favorable clinicopathological features, such as lack of intracranial invasion, less metastases, and longer overall survival. Conclusion The microarray CGH results enabled to better define hotspots of chromosomal gains and losses for further investigation of genes involved in the tumorigenesis of sinonasal adenocarcinoma. In addition, the data allowed classification of a group of patients with better clinical outcome. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.20973