Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma

Background Recent studies have indicated hedgehog pathway plays a role in carcinogenesis of certain cancers. We investigated the clinical significance of its signaling components, including Sonic hedgehog (Shh), Patched (Ptch), and Gli‐1, in oral squamous cell carcinoma (OSCC). Methods By immunohist...

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Published in:Head & neck 2012-11, Vol.34 (11), p.1556-1561
Main Authors: Wang, Yi-Fen, Chang, Chun-Ju, Lin, Chin-Ping, Chang, Shyue-Yih, Chu, Pen-Yuan, Tai, Shyh-Kuan, Li, Wing-Yin, Chao, K.S. Clifford, Chen, Yu-Jen
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Transformation, Neoplastic - metabolism
Female
Gene Expression Regulation, Neoplastic
hedgehog
Hedgehog Proteins - metabolism
Humans
Immunohistochemistry
Male
Medical sciences
metastasis
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
oral squamous cell carcinoma
Otorhinolaryngology. Stomatology
Prognosis
Signal Transduction
survival
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background Recent studies have indicated hedgehog pathway plays a role in carcinogenesis of certain cancers. We investigated the clinical significance of its signaling components, including Sonic hedgehog (Shh), Patched (Ptch), and Gli‐1, in oral squamous cell carcinoma (OSCC). Methods By immunohistochemistry, we determined Shh, Ptch, and Gli‐1 expression in surgical specimens from 40 patients with OSCC. The relationship between expression of these molecules and clinicopathologic variables were assessed by chi‐square analysis. Statistical difference of survival was compared using log‐rank test. Results Ptch overexpression was associated with lymphatic metastasis (p = .028). Nuclear Gli‐1 overexpression correlated with primary tumor size (p = .001), lymphatic metastasis (p = .011), and tumor recurrence (p = .008). Overexpression of Ptch (p = .020) or Gli‐1 (p = .002) in OSCC indicated poor prognosis in the univariate survival analysis. Conclusion Our results suggest sonic hedgehog (Shh) pathway plays an important role in OSCC progression and should be considered a potential therapeutic target. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21958