Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16 INK4a status

Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16 in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV...

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Published in:Head & neck 2022-01, Vol.44 (1), p.122-133
Main Authors: Sichero, Laura, Tagliabue, Marta, Mota, Giana, Ferreira, Silvaneide, Nunes, Rafaella A L, Castañeda, Carlos Arturo, Castillo, Miluska, Correa, Rita Mariel, Perdomo, Sandra, Rodríguez-Urrego, Paula A, Matos, Leandro Luongo, Mohssen, Ansarin, Gheit, Tarik, Tommasino, Massimo, Chiocca, Susanna, Villa, Luisa Lina
Format: Article
Language:English
Subjects:
Alphapapillomavirus - genetics
Biomarkers, Tumor - genetics
Carcinoma, Squamous Cell - epidemiology
Cyclin-Dependent Kinase Inhibitor p16
DNA, Viral - genetics
Head and Neck Neoplasms - epidemiology
Humans
Latin America
Papillomaviridae - genetics
Papillomavirus Infections - epidemiology
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Summary:Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16 in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16 immunohistochemistry. HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16 positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26912