The fasting B6 vitamer profile and response to a pyridoxine load in normal and cirrhotic subjects

This study established the fasting plasma and urine profiles of vitamin B6 in cirrhotics and assessed the response to an oral dose of pyridoxine. High‐performance liquid chromatography was used to measure all vitameric coenzymatic and degradatory forms. In 31 patients with cirrhosis and 15 healthy c...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1986-05, Vol.6 (3), p.464-471
Main Authors: Henderson, J. Michael, Codner, Mark A., Hollins, Bettye, Kutner, Michael H., Merrill, Alfred H.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chromatography, High Pressure Liquid
Fasting
Female
Humans
Hydrolysis
Liver Cirrhosis - metabolism
Liver Cirrhosis, Alcoholic - metabolism
Male
Medical sciences
Middle Aged
Miscellaneous
Pharmacology. Drug treatments
Pyridoxal Phosphate - blood
Pyridoxic Acid - analysis
Pyridoxine - analysis
Pyridoxine - pharmacology
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Summary:This study established the fasting plasma and urine profiles of vitamin B6 in cirrhotics and assessed the response to an oral dose of pyridoxine. High‐performance liquid chromatography was used to measure all vitameric coenzymatic and degradatory forms. In 31 patients with cirrhosis and 15 healthy controls, fasting plasma and 24‐hr urine collection showed: plasma pyridoxal‐5′‐phosphate, the biologically active form, was significantly (p
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840060324