Neopterin and soluble tumor necrosis factor receptor type I in alcohol‐induced cirrhosis

Alcohol‐induced cirrhosis (AC) is accompanied by disturbances of immune function and cytokine production. To better define the pattern of cytokine synthesis in this disease and to relate it to the immune activation state, we measured circulating levels of soluble tumor necrosis factor receptor p55 (...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1995-04, Vol.21 (4), p.976-978
Main Authors: Diez‐Ruiz, Antonio, Tilz, Gernot P., Gutierrez‐Gea, Francisco, Gil‐Extremera, Blas, Murr, Christian, Wachter, Helmut, Fuchs, Dietmar
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopterins - analogs & derivatives
Biopterins - blood
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Cirrhosis, Alcoholic - blood
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Neopterin
Other diseases. Semiology
Receptors, Tumor Necrosis Factor - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alcohol‐induced cirrhosis (AC) is accompanied by disturbances of immune function and cytokine production. To better define the pattern of cytokine synthesis in this disease and to relate it to the immune activation state, we measured circulating levels of soluble tumor necrosis factor receptor p55 (sTNFR‐55) and neopterin in a group of 85 patients with AC (classified according to the Child‐Pugh score of severity of liver disease) and 43 healthy volunteers. Serum concentrations of sTNFR‐55 and neopterin were significantly raised in patients with AC. Moreover, concentrations of sTNFR‐55 were significantly higher in patients with more severe disease compared with the group with lower severity. There were significant correlations between sTNFR‐55 and neopterin levels in patients and controls. The results contribute to affirm the existence of an immune activation state in AC that could be responsible for the development of the disease and clinical complications. (HEPATOLOGY 1995; 21:976–978.)
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840210414